Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-1-[Tris(1-Methylethyl)Silyl]- is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrrolopyridine core protected by a bulky triisopropylsilyl (TIPS) group. This compound is a critical building block in modern organic synthesis, valued for its role in constructing complex nitrogen-containing heterocycles prevalent in active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted small-molecule therapies.
• Agrochemical Research: Used in the development of novel herbicides and fungicides that leverage its heterocyclic structure for biological activity.
• Material Science: Serves as a monomer or functional unit in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Academic & Contract Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form new carbon-carbon bonds.
• Protecting Group Strategy: The TIPS group allows for selective functionalization at other positions on the pyrrolopyridine ring system, which is later deprotected under mild conditions.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	640735-24-6
Molecular Formula	C16H25BrN2Si
Molecular Weight	353.38 g/mol
Synonyms	4-Bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 4-Bromo-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-4-bromo-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]- (related); TIPS-4-Bromo-7-azaindole; 4-Bromo-1-TIPS-7-azaindole; 4-Bromo-7-azaindole, 1-TIPS protected; 4-Bromo-1-(triisopropylsilyl)-7-azaindole
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-1-[Tris(1-Methylethyl)Silyl]- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.