Description

2-Pyridinecarbonyl Chloride, 4-(Trifluoromethyl)- (9Ci) is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in the reactive acid chloride group and the electron-withdrawing trifluoromethyl substituent, which enables precise derivatization to create novel molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized pyridine-based ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Functional Material Development: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers requiring specific fluorinated aromatic components.
• Custom Chemical Synthesis: A versatile reagent for contract research organizations (CROs) and custom synthesis houses to fulfill client-specific molecular targets.
• Bioconjugation and Probe Synthesis: Useful for labeling biomolecules or creating fluorescent probes and other diagnostic tools due to its reactive acyl chloride functionality.

Basic Information

Product Name	2-Pyridinecarbonyl Chloride, 4-(Trifluoromethyl)- (9Ci)
CAS No.	640296-12-4
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	4-(Trifluoromethyl)picolinoyl chloride; 4-(Trifluoromethyl)pyridine-2-carbonyl chloride; 2-Pyridinecarbonyl chloride, 4-(trifluoromethyl)-; 4-Trifluoromethylpicolinic acid chloride; Picolinoyl chloride, 4-trifluoromethyl-; Isonicotinoyl chloride, 6-trifluoromethyl- (related isomer); 4-Trifluoromethyl-2-pyridinecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Pyridinecarbonyl Chloride, 4-(Trifluoromethyl)- is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and FTIR, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades or analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.