Description

3-(4-Fluoro-Phenyl)-Isoxazole-5-Carboxylic Acid Ethyl Ester is a high-purity fluorinated isoxazole derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its versatile chemical structure, which serves as a key intermediate for constructing more complex molecules in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to incorporate the 4-fluorophenyl-isoxazole pharmacophore into novel active compounds.

Application

This specialized chemical intermediate enables innovation across several high-value research and manufacturing sectors:

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and insecticides, where the fluorinated isoxazole moiety can enhance biological activity and environmental stability.
• Material Science: Used in the research and development of advanced organic electronic materials, liquid crystals, and functional polymers.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical pathway analysis and drug discovery.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	3-(4-Fluoro-Phenyl)-Isoxazole-5-Carboxylic Acid Ethyl Ester
CAS No.	640291-92-5
Molecular Formula	C12H10FNO3
Molecular Weight	235.21 g/mol
Synonyms	Ethyl 3-(4-fluorophenyl)-1,2-oxazole-5-carboxylate; 5-Isoxazolecarboxylic acid, 3-(4-fluorophenyl)-, ethyl ester; 3-(p-Fluorophenyl)-5-carbethoxyisoxazole; Ethyl 3-(4-fluorophenyl)isoxazole-5-carboxylate; 640291-92-5; 3-(4-Fluorophenyl)isoxazole-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of 3-(4-Fluoro-Phenyl)-Isoxazole-5-Carboxylic Acid Ethyl Ester adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure consistency and compliance with research-grade standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.