Description

(S)-1-Boc-2-(2-Oxoethyl)Piperidine CAS NO 639458-43-8 is a high-purity, chiral piperidine derivative featuring a Boc-protected amine and a reactive oxoethyl side chain. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile chiral building block for the synthesis of complex bioactive molecules. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing nitrogen-containing heterocycles with precise stereochemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Serves as a chiral precursor in catalytic asymmetric reactions to introduce stereocenters into complex molecular architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Peptidomimetic Development: The piperidine scaffold is integral for creating non-peptide analogs that mimic peptide function for enhanced stability and bioavailability.
• Agrochemical Synthesis: Building block for novel chiral pesticides and herbicides requiring specific stereoisomers for optimal activity.
• Ligand and Catalyst Preparation: Used to synthesize chiral ligands for metal-catalyzed reactions or organocatalysts.

Basic Information

Product Name	(S)-1-Boc-2-(2-Oxoethyl)Piperidine
CAS No.	639458-43-8
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	1-Boc-2-(2-oxoethyl)piperidine, (S)-; (S)-tert-Butyl 2-(2-oxoethyl)piperidine-1-carboxylate; (S)-1-(tert-Butoxycarbonyl)-2-(2-oxoethyl)piperidine; (S)-N-Boc-2-(2-oxoethyl)piperidine; (S)-2-(2-Oxoethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; (S)-1-Boc-2-(2-oxoethyl)piperidine; (S)-Boc-2-(2-oxoethyl)piperidine
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-2-(2-Oxoethyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We are committed to providing material that supports your regulatory filings and process development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.