Description

3-Bromo-5-(2-Trimethylsilyl)Ethynyl)Pyridine is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromo substituent and a protected ethynyl group, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by material scientists developing specialty polymers and ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Building Block: Employed in the creation of functionalized polymers, liquid crystals, and organic electronic materials.
• Ligand and Catalyst Development: The pyridine and alkyne functionalities make it a valuable starting point for synthesizing novel chelating ligands and organometallic catalysts.
• Cross-Coupling Reactions: The bromo group is an excellent handle for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl and conjugated systems.
• Chemical Biology Probes: Used to develop molecular probes and tags for studying biological processes due to its modifiable handles.

Basic Information

Product Name	3-Bromo-5-(2-Trimethylsilyl)Ethynyl)Pyridine
CAS No.	639011-64-6
Molecular Formula	C₁₀H₁₂BrNSi
Molecular Weight	254.20 g/mol
Synonyms	3-Bromo-5-[(trimethylsilyl)ethynyl]pyridine; 5-Bromo-3-(2-trimethylsilylethynyl)pyridine; Pyridine, 3-bromo-5-[(trimethylsilyl)ethynyl]-; 3-Bromo-5-(trimethylsilylethynyl)pyridine; 3-Bromo-5-(TMS-ethynyl)pyridine; 3-Bromo-5-ethynylpyridine, TMS-protected; TMS-protected 3-Bromo-5-ethynylpyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(2-Trimethylsilyl)Ethynyl)Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to verify specifications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Incompatible with strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.