Description

Spiro[4H-3,1-Benzoxazine-4,1-Cyclobutan]-2(1H)-One (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic benzoxazine structure. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex heterocyclic molecules. It is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for developing new active ingredients and fine-tuning synthetic pathways.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its heterocyclic framework.
• Material Science Precursor: Serves as a monomer or precursor in the research of specialty polymers and advanced organic materials.
• Academic & Industrial R&D: Employed in chemical libraries and for method development in organic synthesis laboratories worldwide.
• Ligand and Catalyst Development: Its rigid spiro structure makes it a candidate for designing novel chiral ligands and organocatalysts.

Basic Information

Item	Detail
Product Name	Spiro[4H-3,1-Benzoxazine-4,1-Cyclobutan]-2(1H)-One (9Ci)
CAS No.	638989-35-2
Molecular Formula	C11H9NO2
Molecular Weight	187.20 g/mol
Synonyms	Spiro[cyclobutane-1,4'-[4H]benzoxazine]-2'(1'H)-one; 1'H-Spiro[cyclobutane-1,4'-benzoxazine]-2'-one; 638989-35-2; Spiro(cyclobutane-1,4'-(4'H)-benzoxazine)-2'(1'H)-one; Spirobenzoxazinone derivative
EINECS	Contact for details

Quality Control

Our Spiro[4H-3,1-Benzoxazine-4,1-Cyclobutan]-2(1H)-One (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.