Description

Cyclopropanecarboxylic Acid, 2-Acetyl-3-Nitro-, Methyl Ester, (1R,2R,3R)-Rel- is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its unique cyclopropane ring system, coupled with strategically positioned acetyl and nitro functional groups, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in programs targeting central nervous system (CNS) disorders and anti-infectives.
• Agrochemical Synthesis: Serves as a precursor in the design and synthesis of new generation herbicides and insecticides with potentially improved efficacy and environmental profiles.
• Asymmetric Catalysis Research: Used as a model substrate or a ligand precursor in the development and screening of new asymmetric catalytic reactions.
• Material Science: Investigated as a monomer or cross-linking agent for the creation of specialty polymers with unique thermal or mechanical properties derived from the strained cyclopropane ring.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for methodological studies in synthetic organic chemistry and total synthesis projects.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Acetyl-3-Nitro-, Methyl Ester, (1R,2R,3R)-Rel-
CAS No.	637353-96-9
Molecular Formula	C8H11NO5
Molecular Weight	201.18 g/mol
Synonyms	(1R,2R,3R)-rel-2-Acetyl-3-nitrocyclopropanecarboxylic acid methyl ester; Methyl (1R,2R,3R)-rel-2-acetyl-3-nitrocyclopropanecarboxylate; rel-(1R,2R,3R)-Methyl 2-acetyl-3-nitrocyclopropanecarboxylate; 2-Acetyl-3-nitrocyclopropanecarboxylic acid methyl ester, (1R,2R,3R)-rel-; Nitrocyclopropane ester derivative
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarboxylic Acid, 2-Acetyl-3-Nitro-, Methyl Ester, (1R,2R,3R)-Rel- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity, meeting the exacting standards required for research and development applications. Certificates of Analysis (COA) detailing specifications such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and residual solvent content are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (rel-(1R,2R,3R))
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.