Description

1-Methyl-Pyrrolidine-3-Carboxylic Acid tert-Butyl Ester CAS NO 635700-02-6 is a high-value, protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex nitrogen-containing heterocycles, which are core scaffolds in modern pharmaceuticals. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, including protease inhibitors and neurological agents.
• Agrochemical Synthesis: Building block for developing novel pesticides and herbicides with specific chiral activity.
• Asymmetric Catalysis Ligand Precursor: Used in the preparation of chiral ligands for metal-catalyzed asymmetric reactions.
• Peptidomimetics Research: Core structure for designing and synthesizing peptide mimics to modulate biological pathways.
• Chemical Biology Probes: Intermediate in the creation of labeled compounds and probes for studying enzyme function and receptor binding.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	1-Methyl-Pyrrolidine-3-Carboxylic Acid tert-Butyl Ester
CAS No.	635700-02-6
Molecular Formula	C10H19NO2
Molecular Weight	185.26 g/mol
Synonyms	tert-Butyl 1-methyl-3-pyrrolidinecarboxylate; 1-Methyl-3-pyrrolidinecarboxylic acid tert-butyl ester; 3-(tert-Butoxycarbonyl)-1-methylpyrrolidine; 1-Methylpyrrolidine-3-carboxylic acid tert-butyl ester; N-Methyl-3-pyrrolidinecarboxylic acid tert-butyl ester; 1-Methyl-3-(Boc)pyrrolidine; Boc-1-Methyl-3-pyrrolidinecarboxylate
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-Pyrrolidine-3-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to meet exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and commercial projects with material suitable for research use, pilot plant, and cGMP manufacturing scales.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.