Description

2-Pyrrolidinemethanol,4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-(Phenylmethyl)-,(2S,4S)- is a high-value, stereochemically defined chiral building block and synthetic intermediate. Its core value lies in its protected hydroxyl and amino functionalities, which are critical for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those working on advanced synthetic routes for active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Asymmetric Synthesis: Serves as a precursor for chiral ligands, catalysts, or auxiliaries used in enantioselective transformations.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and conformationally restricted amino acid analogs due to its pyrrolidine scaffold.
• API Development: Integral to the construction of specific pharmacophores in preclinical and process chemistry for new therapeutic agents.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, specialty chemicals.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	2-Pyrrolidinemethanol,4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-(Phenylmethyl)-,(2S,4S)-
CAS No.	635299-82-0
Molecular Formula	C18H31NO2Si
Molecular Weight	321.53 g/mol
Synonyms	(2S,4S)-4-[(tert-Butyldimethylsilyl)oxy]-1-benzyl-2-pyrrolidinemethanol; (2S,4S)-1-Benzyl-4-[(tert-butyldimethylsilyl)oxy]-2-pyrrolidinemethanol; (2S,4S)-1-Benzyl-4-(tert-butyldimethylsiloxy)-2-pyrrolidinemethanol; (2S,4S)-4-(tert-Butyldimethylsiloxy)-1-benzyl-2-hydroxymethylpyrrolidine; 1-Benzyl-4-(TBDMS-oxy)-(2S,4S)-2-pyrrolidinemethanol; TBS-protected (2S,4S)-1-Benzyl-4-hydroxy-2-pyrrolidinemethanol; (2S,4S)-1-Benzyl-4-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinemethanol,4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-(Phenylmethyl)-,(2S,4S)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed under an inert atmosphere to maximize stability, as the compound may be sensitive to moisture and strong bases/fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.