Description

1-Boc-4-Cyano-4-(2-Trifluoromethylphenyl)-Piperidine is a high-value, multi-functional piperidine derivative and a key synthetic intermediate in modern organic chemistry. Its core value lies in the strategic combination of a protected amine (Boc group), a versatile nitrile functionality, and a trifluoromethylphenyl moiety, enabling its use in complex molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, or organic electronic materials due to its rigid, aromatic structure and functional handles.
• Custom Synthesis & Contract Manufacturing: A pivotal intermediate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	1-Boc-4-Cyano-4-(2-Trifluoromethylphenyl)-Piperidine
CAS No.	634465-94-4
Molecular Formula	C18H21F3N2O2
Molecular Weight	354.37 g/mol
Synonyms	1-Boc-4-cyano-4-[2-(trifluoromethyl)phenyl]piperidine; tert-Butyl 4-cyano-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylate; 4-Cyano-4-(2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-cyano-4-(2-trifluoromethylphenyl)piperidine; 4-(2-Trifluoromethylphenyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(2-trifluoromethylphenyl)-4-cyanopiperidine; Piperidine, 1-[(1,1-dimethylethoxy)carbonyl]-4-cyano-4-[2-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Every batch of 1-Boc-4-Cyano-4-(2-Trifluoromethylphenyl)-Piperidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.