Description

1H-Pyrazolo[3,4-C]Pyridine-5-Carbonitrile,3-Iodo- is a high-value heterocyclic building block featuring a fused pyrazolopyridine core with strategically positioned cyano and iodo functional groups. This compound is critical for advanced pharmaceutical research and development, particularly in the synthesis of novel small molecule drug candidates. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and life science industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its reactive iodo and cyano handles.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology: Employed as a probe or linker in the development of chemical tools for biological target identification and validation.
• Cross-Coupling Reactions: The iodo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse compound libraries.
• Nucleophilic Substitution & Cyano Transformation: The cyano group can be further functionalized into amides, acids, or tetrazoles, expanding its utility in molecular design.

Basic Information

Item	Information
Product Name	1H-Pyrazolo[3,4-C]Pyridine-5-Carbonitrile,3-Iodo-
CAS No.	633328-51-5
Molecular Formula	C7H3IN4
Molecular Weight	270.03 g/mol
Synonyms	3-Iodo-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile; 3-Iodo-5-cyano-1H-pyrazolo[3,4-c]pyridine; 1H-Pyrazolo[3,4-c]pyridine-5-carbonitrile, 3-iodo-; 633328-51-5; 3-Iodo-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile; 3-Iodo-5-cyanopyrazolo[3,4-c]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-C]Pyridine-5-Carbonitrile,3-Iodo- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.