Description

2-Iodo-4-Methyl-5-Nitropyridine is a halogenated and nitrated pyridine derivative, a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the strategic positioning of the iodine and nitro groups, which serve as excellent handles for further functionalization via cross-coupling and substitution reactions. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a building block for creating functionalized ligands in catalysis and for synthesizing advanced organic electronic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to form new carbon-carbon bonds.
• Nucleophilic Aromatic Substitution: The nitro group activates the pyridine ring for displacement reactions, allowing for the introduction of amines, alkoxides, and other nucleophiles.
• Chemical Biology & Proteomics: Can be utilized as a tagging or labeling reagent for biomolecules due to its reactive halogen and potential for further modification.

Basic Information

Product Name	2-Iodo-4-Methyl-5-Nitropyridine
CAS No.	633328-46-8
Molecular Formula	C6H5IN2O2
Molecular Weight	264.02 g/mol
Synonyms	5-Nitro-4-methyl-2-iodopyridine; 4-Methyl-5-nitro-2-iodopyridine; 2-Iodo-4-methyl-5-nitropyridine; Pyridine, 2-iodo-4-methyl-5-nitro-; Iodomethylnitropyridine
EINECS	Contact for details

Quality Control

Our 2-Iodo-4-Methyl-5-Nitropyridine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong reducing agents and bases. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.