Description

3-(4-Boc-Piperazino)-2-Chloropyridine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine ring protected by a tert-butoxycarbonyl (Boc) group and a reactive 2-chloropyridine moiety. This compound matters because it serves as a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), enabling medicinal chemists to construct sophisticated molecular architectures with precision. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component for constructing bifunctional molecules in targeted protein degradation platforms.
• Kinase Inhibitor Synthesis: Employed in the construction of heterocyclic cores for potential kinase inhibitors, relevant in cancer research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Chemical Biology Tool Development: Utilized to create chemical probes for studying biological pathways and protein function.

Basic Information

Product Name	3-(4-Boc-Piperazino)-2-Chloropyridine
CAS No.	633283-64-4
Molecular Formula	C14H20ClN3O2
Molecular Weight	297.78 g/mol
Synonyms	2-Chloro-3-(4-Boc-piperazin-1-yl)pyridine; 1-Boc-4-(2-Chloropyridin-3-yl)piperazine; tert-Butyl 4-(2-chloropyridin-3-yl)piperazine-1-carboxylate; 3-(1-Boc-piperazin-4-yl)-2-chloropyridine; 2-Chloro-3-(N-Boc-piperazinyl)pyridine; 2-Chloro-3-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyridine; 3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-chloropyridine
EINECS	Contact for details

Quality Control

Our 3-(4-Boc-Piperazino)-2-Chloropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. For advanced applications, we can supply material that meets the stringent standards required for pharmaceutical development under a Quality Agreement.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.