Description

4-(2-Trifluoromethyl-Pyridin-4-Yloxy)-Phenylamine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct trifluoromethylpyridine and aniline structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular modifications. Pharmaceutical R&D teams and fine chemical manufacturers need this precise building block to develop next-generation drugs, leveraging its unique properties for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can enhance lipophilicity and biological activity.
• Material Science: Serves as a precursor for functionalized polymers and advanced organic electronic materials due to its aromatic amine and heterocyclic components.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Buchwald-Hartwig amination) to create complex, nitrogen-containing aromatic systems for various research applications.
• Ligand & Catalyst Development: Utilized in the design of novel ligands for catalytic systems and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(2-Trifluoromethyl-Pyridin-4-Yloxy)-Phenylamine
CAS No.	630125-71-2
Molecular Formula	C12H9F3N2O
Molecular Weight	254.21 g/mol
Synonyms	4-(2-(Trifluoromethyl)pyridin-4-yloxy)aniline; 4-Amino-4'-(2-trifluoromethyl-4-pyridyloxy)diphenyl ether (incorrect but common misnomer); 4-(2-Trifluoromethyl-4-pyridyloxy)phenylamine; 1-Amino-4-[(2-trifluoromethyl-4-pyridinyl)oxy]benzene; Benzenamine, 4-[(2-(trifluoromethyl)-4-pyridinyl)oxy]-; 630125-71-2; 4-(2-Trifluoromethylpyridin-4-yloxy)aniline
EINECS	Contact for details

Quality Control

Our 4-(2-Trifluoromethyl-Pyridin-4-Yloxy)-Phenylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with exacting R&D and production standards. Certificates of Analysis (COA) documenting full specifications are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.