Description

Mipomersen Sodium is the sodium salt form of mipomersen, a second-generation antisense oligonucleotide (ASO) therapeutic agent. This compound is specifically designed to inhibit the production of apolipoprotein B-100 (apoB-100), a key protein in the synthesis of atherogenic lipoproteins. It is primarily utilized as a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) in the development and manufacturing of targeted therapies for severe lipid disorders.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of lipid-lowering therapeutics.
• Research & Development of antisense oligonucleotide-based drugs targeting genetic metabolic diseases.
• Preclinical and Clinical Studies investigating novel treatments for homozygous familial hypercholesterolemia (HoFH).
• Biochemical Research as a tool compound to study apoB-100 metabolism and lipid transport pathways.
• Pharmaceutical Intermediates for the synthesis of more complex oligonucleotide conjugates.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Mipomersen Sodium
CAS No.	629167-92-6
Molecular Formula	C230H305N67O122P20S20Na20
Molecular Weight	7594.8 g/mol (free acid basis)
Synonyms	Mipomersen sodium salt; ISIS 301012 sodium salt; Kynamro (brand name); Apolipoprotein B-100 synthesis inhibitor; ApoB-100 antisense oligonucleotide; 20-mer phosphorothioate oligonucleotide sodium salt; 5'-d(CmUmCmAmAmGmAmTmCmTmGmCmTmCmTmGmCmAm)-3' sodium salt (fully 2'-O-methoxyethyl modified)
EINECS	Contact for details

Quality Control

Our Mipomersen Sodium is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch is subjected to a comprehensive suite of analytical tests to ensure identity, purity, potency, and consistency. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing specifications and test results are available for every lot, ensuring compliance with cGMP guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (Total Oligonucleotide)	≥ 85.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 15.0%
Water Content (KF)	≤ 10.0%
Residual Solvents (GC)	Meets ICH guidelines
Endotoxin (LAL)	< 10.0 EU/mg
Biopurity (Sterility)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.