Description

Cyclobutanecarboxylic Acid, 3-Hydroxy-1-Methyl-, Methyl Ester, cis- (9Ci) is a specialized chiral building block and intermediate of significant interest in advanced organic synthesis. Its unique cis-fused cyclobutane ring structure with adjacent hydroxyl and ester functionalities makes it a valuable scaffold for constructing complex molecules with defined stereochemistry. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of proprietary drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and insecticides, where the cyclobutane core contributes to unique biological activity.
• Advanced Material Chemistry: Serves as a monomer or functional modifier in the development of specialty polymers and liquid crystals with tailored properties.
• Asymmetric Catalysis Research: Employed as a test substrate or ligand precursor in the development of new catalytic systems for stereoselective transformations.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing complex, high-value aroma chemicals with specific olfactory profiles.
• Academic & Contract Research: Utilized in universities and CROs for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Hydroxy-1-Methyl-, Methyl Ester, cis- (9Ci)
CAS No.	626238-08-2
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	cis-3-Hydroxy-1-methylcyclobutanecarboxylic acid methyl ester; Methyl cis-3-hydroxy-1-methylcyclobutanecarboxylate; (1R,3S)-3-Hydroxy-1-methylcyclobutanecarboxylic acid methyl ester; (1S,3R)-3-Hydroxy-1-methylcyclobutanecarboxylic acid methyl ester; 3-Hydroxy-1-methylcyclobutanecarboxylic Acid Methyl Ester, cis-; cis-Methyl 3-hydroxy-1-methylcyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 3-Hydroxy-1-Methyl-, Methyl Ester, cis- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, and NMR to confirm identity, purity, and isomeric composition. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.