Description

L-Proline, 5-Hydroxy-, Methyl Ester, (5R)- (9Ci) is a high-purity, chiral proline derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of pharmaceuticals and bioactive compounds. It is essential for research and production in pharmaceutical development, agrochemical synthesis, and specialized fine chemical manufacturing where precise stereochemistry is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used in medicinal chemistry to design and synthesize peptide analogs and conformationally constrained scaffolds.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for stereoselective transformations.
• Agrochemical Synthesis: A building block for creating advanced, chiral active ingredients with specific biological activity.
• Biochemical Research: Utilized in studies of collagen metabolism and as a tool compound in enzymology due to its hydroxyproline structure.
• Fine Chemical Production: Serves as a starting material for custom synthesis and the manufacture of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	L-Proline, 5-Hydroxy-, Methyl Ester, (5R)- (9Ci)
CAS No.	625441-33-0
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	(2S,5R)-Methyl 5-hydroxypyrrolidine-2-carboxylate; Methyl (2S,5R)-5-hydroxypyrrolidine-2-carboxylate; (5R)-Hydroxy-L-proline methyl ester; Methyl (5R)-hydroxy-L-prolinate; L-Hydroxyproline methyl ester; trans-4-Hydroxy-L-proline methyl ester (stereospecific); (2S,5R)-5-Hydroxypyrrolidine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 5-Hydroxy-, Methyl Ester, (5R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.