Description

6-Cyclopropyl-2-[(2-Oxopropyl)Sulfanyl]-4-(Trifluoromethyl)Nicotinonitrile is a high-value, multifunctional heterocyclic building block designed for advanced chemical synthesis. This compound is strategically engineered to serve as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and nitrile functionalities are highly prized. It is primarily sought after by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as liquid crystals or functional polymers, due to its rigid, substituted pyridine core.
• Chemical Biology Probes: Employed in the development of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	6-Cyclopropyl-2-[(2-Oxopropyl)Sulfanyl]-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	625377-44-8
Molecular Formula	C13H11F3N2OS
Molecular Weight	300.30 g/mol
Synonyms	2-[(2-Oxopropyl)thio]-6-cyclopropyl-4-(trifluoromethyl)nicotinonitrile; 6-Cyclopropyl-2-[(2-oxopropyl)thio]-4-(trifluoromethyl)-3-pyridinecarbonitrile; 4-(Trifluoromethyl)-6-cyclopropyl-2-[(2-oxopropyl)thio]nicotinonitrile; 6-Cyclopropyl-2-(2-oxopropylsulfanyl)-4-(trifluoromethyl)pyridine-3-carbonitrile; Nicotinonitrile, 6-cyclopropyl-2-[(2-oxopropyl)thio]-4-(trifluoromethyl)-; 625377-44-8
EINECS	Contact for details

Quality Control

Our 6-Cyclopropyl-2-[(2-Oxopropyl)Sulfanyl]-4-(Trifluoromethyl)Nicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.