Description

4-(Trifluoromethyl)-6-(4-Fluorophenyl)-1,2-Dihydro-2-Thioxopyridine-3-Carbonitrile is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and fluorophenyl substituents impart desirable biological and physicochemical properties. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating new molecules with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for developing advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API batches for clinical trials.

Basic Information

Product Name	4-(Trifluoromethyl)-6-(4-Fluorophenyl)-1,2-Dihydro-2-Thioxopyridine-3-Carbonitrile
CAS No.	625370-80-1
Molecular Formula	C13H6F4N2S
Molecular Weight	298.26 g/mol
Synonyms	4-(Trifluoromethyl)-6-(4-fluorophenyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile; 6-(4-Fluorophenyl)-4-(trifluoromethyl)-2-thioxo-1,2-dihydro-3-pyridinecarbonitrile; 2-Thioxo-1,2-dihydro-4-(trifluoromethyl)-6-(4-fluorophenyl)pyridine-3-carbonitrile; 4-(Trifluoromethyl)-6-(p-fluorophenyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile; 625370-80-1; Fluorinated pyridinethione derivative
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)-6-(4-Fluorophenyl)-1,2-Dihydro-2-Thioxopyridine-3-Carbonitrile undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system is designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by IR, NMR, and MS), and impurity profile is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.