Description

1-(3-Nitro-Benzenesulfonyl)-Piperidine-4-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and benzenesulfonyl protecting group. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. Pharmaceutical manufacturers, contract research organizations (CROs), and fine chemical synthesis specialists need this ester for constructing novel drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug molecules, especially those containing piperidine or sulfonamide pharmacophores.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization stages for constructing and screening compound libraries.
• Protease Inhibitor Development: Serves as a building block for potential inhibitors due to its sulfonamide moiety, which can mimic peptide bonds.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of specialized, non-commercial compounds for client projects.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-(3-Nitro-Benzenesulfonyl)-Piperidine-4-Carboxylic Acid Ethyl Ester
CAS No.	625106-78-7
Molecular Formula	C14H18N2O6S
Molecular Weight	342.37 g/mol
Synonyms	Ethyl 1-[(3-nitrophenyl)sulfonyl]-4-piperidinecarboxylate; Ethyl 1-(3-nitrobenzenesulfonyl)piperidine-4-carboxylate; 4-Piperidinecarboxylic acid, 1-[(3-nitrophenyl)sulfonyl]-, ethyl ester; 1-(3-Nitrobenzenesulfonyl)piperidine-4-carboxylic acid ethyl ester; 1-(3-Nitro-phenylsulfonyl)-piperidine-4-carboxylic acid ethyl ester; 3-Nitro-N-(4-(ethoxycarbonyl)piperidin-1-yl)benzenesulfonamide (tautomeric form); 625106-78-7
EINECS	Contact for details

Quality Control

Our 1-(3-Nitro-Benzenesulfonyl)-Piperidine-4-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.