Description

3-Bromo-6-(Phenylsulfonyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused naphthyridine core functionalized with bromo and phenylsulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile bromine handle for further functionalization.
• Process Development: Serves as a starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material manufacturing.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions.

Basic Information

Product Name	3-Bromo-6-(Phenylsulfonyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine
CAS No.	625099-99-2
Molecular Formula	C₁₈H₁₇BrN₂O₂S
Molecular Weight	405.31 g/mol
Synonyms	3-Bromo-6-(benzenesulfonyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; 5,6,7,8-Tetrahydro-3-bromo-6-(phenylsulfonyl)-1,6-naphthyridine; 625099-99-2; 3-Bromo-6-(phenylsulfonyl)-5,6,7,8-tetrahydro[1,6]naphthyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-6-(Phenylsulfonyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.