Description

1,6-Naphthyridine-6(5H)-Carboxylic Acid, 3-Chloro-7,8-Dihydro-, 1,1-Dimethylethyl Ester is a high-value, advanced pharmaceutical intermediate characterized by its complex naphthyridine core and protected carboxylic acid group. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring sophisticated heterocyclic scaffolds. Research and development teams in the pharmaceutical and biotechnology sectors need this precise chemical for constructing molecules with targeted biological activity, making it essential for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates, especially those targeting kinase inhibition or other enzyme-related pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: The tert-butyl ester group provides a protected carboxylic acid functionality, allowing for selective reactions on other parts of the molecule in complex synthetic routes.
• Agrochemical Research: May be investigated as an intermediate for developing new crop protection agents due to the bioactive naphthyridine structure.
• Material Science Exploration: Potential use in the development of organic electronic materials or ligands for catalytic systems, leveraging its conjugated heterocyclic system.

Basic Information

Item	Details
Product Name	1,6-Naphthyridine-6(5H)-Carboxylic Acid, 3-Chloro-7,8-Dihydro-, 1,1-Dimethylethyl Ester
CAS No.	625099-34-5
Molecular Formula	C15H17ClN2O2
Molecular Weight	292.76 g/mol
Synonyms	tert-Butyl 3-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate; 3-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylic acid tert-butyl ester; 6-(tert-Butoxycarbonyl)-3-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine; Boc-3-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine; 3-Chloro-7,8-dihydro-1,6-naphthyridin-6(5H)-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1,6-Naphthyridine-6(5H)-Carboxylic Acid, 3-Chloro-7,8-Dihydro-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided and available upon request. We support development and commercial projects with custom purity grades to meet specific research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Any single unknown impurity	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.