Description

tert-Butyl 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine-6-Carboxylate is a high-value, advanced pharmaceutical intermediate characterized by its naphthyridine core and trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for constructing novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of new drug candidates, particularly in therapeutic areas requiring sophisticated heterocyclic architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The naphthyridine structure is relevant in the development of inhibitors for various enzymes, including kinases and proteases.
• CNS Drug Candidates: Serves as a precursor in the research of potential central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Can be utilized in the research and development of novel agrochemicals and pesticides.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways.

Basic Information

Product Name	tert-Butyl 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine-6-Carboxylate
CAS No.	624734-26-5
Molecular Formula	C14H17F3N2O2
Molecular Weight	302.29 g/mol
Synonyms	6-(tert-Butoxycarbonyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; tert-Butyl 3-(trifluoromethyl)-5,8-dihydro-1,6-naphthyridine-6(7H)-carboxylate; 3-Trifluoromethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylic acid tert-butyl ester; 1,6-Naphthyridine-6-carboxylic acid, 3-(trifluoromethyl)-5,6,7,8-tetrahydro-, 1,1-dimethylethyl ester; TBTC; CAS 624734-26-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.