Description

tert-Butyl 4-(5-Bromopyridin-2-yl)piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and a brominated pyridine moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on developing new drug candidates, particularly in the areas of central nervous system (CNS) and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new therapeutic agents.
• Library Synthesis: Employed in combinatorial chemistry for the generation of diverse compound libraries for high-throughput screening.
• CNS Drug Development: The piperidine scaffold is common in molecules targeting neurological pathways, making this intermediate valuable for CNS drug discovery.
• Kinase Inhibitor Synthesis: The bromopyridine group is a common handle for further functionalization in the creation of potential kinase inhibitors for oncology.
• Custom Synthesis: Serves as a starting material for contract manufacturing organizations (CMOs) performing custom synthesis for client-specific projects.

Basic Information

Product Name	tert-Butyl 4-(5-Bromopyridin-2-yl)piperidine-1-carboxylate
CAS No.	622387-27-3
Molecular Formula	C15H21BrN2O2
Molecular Weight	341.25 g/mol
Synonyms	1-Boc-4-(5-bromopyridin-2-yl)piperidine; 1-(tert-Butoxycarbonyl)-4-(5-bromo-2-pyridyl)piperidine; 4-(5-Bromo-2-pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(5-bromo-2-pyridinyl)-1-piperidinecarboxylate; 4-(5-Bromopyridin-2-yl)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(5-bromopyridin-2-yl)piperidine; 622387-27-3; 1-N-Boc-4-(5-bromopyridin-2-yl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Bromopyridin-2-yl)piperidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.