Description

2-Chloro-5-Iodobenzoic Acid Methyl Ester is a versatile halogenated aromatic ester building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and iodo substituents, makes it a valuable precursor for constructing complex molecules via cross-coupling reactions and further functional group transformations. This intermediate is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex aromatic scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where halogenated benzoic acid derivatives are active components.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands used in transition metal catalysis, such as Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions.
• Material Science: Employed in the research and development of organic electronic materials, liquid crystals, and advanced polymers.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological processes due to the reactivity of the iodine atom.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses producing bespoke organic compounds for client R&D projects.

Basic Information

Product Name	2-Chloro-5-Iodobenzoic Acid Methyl Ester
CAS No.	620621-48-9
Molecular Formula	C8H6ClIO2
Molecular Weight	296.49 g/mol
Synonyms	Methyl 2-Chloro-5-iodobenzoate; Benzoic acid, 2-chloro-5-iodo-, methyl ester; 2-Chloro-5-iodobenzoic acid methyl ester; Methyl 5-iodo-2-chlorobenzoate; 5-Iodo-2-chlorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodobenzoic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for that lot. We support cGMP-compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The compound is light-sensitive (store away from light) and should be handled in accordance with good laboratory practices for chemicals.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.