Description

1-(Azidomethyl)-3,5-Bis(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic building block containing both azide and trifluoromethyl groups. This compound is critical for advanced synthesis, particularly in click chemistry and the development of novel materials with tailored properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Agrochemical Research: Used to introduce trifluoromethyl and triazole motifs into novel herbicide and pesticide candidates, enhancing biological activity and metabolic stability.
• Material Science: Building block for functional polymers, dendrimers, and liquid crystals where the azide group enables efficient cross-linking and modular assembly.
• Bioconjugation & Probe Development: Facilitates the labeling of biomolecules (proteins, oligonucleotides) for diagnostic assays and imaging applications.
• Energetic Materials Research: Serves as a precursor in the study of high-energy-density materials (HEDMs) due to its azide functionality.
• Organic Synthesis: Versatile reagent for introducing the 3,5-bis(trifluoromethyl)benzyl moiety into complex organic molecules, leveraging the electron-withdrawing effect of the CF3 groups.

Basic Information

Product Name	1-(Azidomethyl)-3,5-Bis(Trifluoromethyl)Benzene
CAS No.	620533-92-8
Molecular Formula	C10H5F6N3
Molecular Weight	281.16 g/mol
Synonyms	α-Azido-3,5-bis(trifluoromethyl)toluene; 3,5-Bis(trifluoromethyl)benzyl azide; (Azidomethyl)-3,5-bis(trifluoromethyl)benzene; 1-(Azidomethyl)-3,5-bis(trifluoromethyl)benzene; Azidomethylbis(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 1-(Azidomethyl)-3,5-Bis(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) under an inert atmosphere (e.g., nitrogen or argon) to minimize the risk of oxidation and degradation. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.