Description

1-Boc-4-Cyano-4-(2,5-Difluorophenyl)-Piperidine is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This compound serves as a critical building block for the synthesis of complex molecules, particularly in the development of targeted therapeutics. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical industries, where precise chemical architecture is required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Protease Inhibitor Development: Used in research and production of protease inhibitors, leveraging the piperidine scaffold and cyano group.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce the protected piperidine moiety with specific substitution patterns.
• Bioconjugation & Labeling: The reactive cyano group can be utilized for further chemical modifications and bioconjugation strategies.

Basic Information

Product Name	1-Boc-4-Cyano-4-(2,5-Difluorophenyl)-Piperidine
CAS No.	619292-29-4
Molecular Formula	C17H20F2N2O2
Molecular Weight	322.35 g/mol
Synonyms	1-Boc-4-cyano-4-(2,5-difluorophenyl)piperidine; tert-Butyl 4-cyano-4-(2,5-difluorophenyl)piperidine-1-carboxylate; 4-Cyano-4-(2,5-difluorophenyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-cyano-4-(2,5-difluorophenyl)piperidine; 4-(2,5-Difluorophenyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester; BOC-4-Cyano-4-(2,5-Difluorophenyl)Piperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Cyano-4-(2,5-Difluorophenyl)-Piperidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting compliance in cGMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.