Description

(R)-(+)-1-(4-Bromophenyl)Ethyl Isocyanate is a high-purity, chiral organic building block characterized by its reactive isocyanate group and brominated aromatic ring. This compound matters as a critical intermediate for the synthesis of enantiomerically pure compounds, enabling the development of advanced materials and pharmaceuticals with specific stereochemical requirements. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and CNS-targeting drugs.
• Agrochemical Synthesis: Used in the research and production of chiral herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Incorporated into specialty polymers, such as polyurethanes and polyureas, to impart specific optical or mechanical properties.
• Chemical Biology Probes: Utilized in the creation of isocyanate-based probes for studying enzyme activity and protein labeling.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring a brominated, chiral isocyanate moiety.

Basic Information

Product Name	(R)-(+)-1-(4-Bromophenyl)Ethyl Isocyanate
CAS No.	618461-78-2
Molecular Formula	C9H8BrNO
Molecular Weight	226.07 g/mol
Synonyms	(R)-1-(4-Bromophenyl)ethyl isocyanate; (R)-(+)-1-(p-Bromophenyl)ethyl isocyanate; (R)-α-Methyl-4-bromobenzyl isocyanate; (+)-1-(4-Bromophenyl)ethyl isocyanate; (R)-1-(4-Bromophenyl)ethan-1-yl isocyanate; p-Bromo-(R)-α-methylbenzyl isocyanate; (R)-4-Bromo-α-methylbenzyl isocyanate
EINECS	Contact for details

Quality Control

Every batch of (R)-(+)-1-(4-Bromophenyl)Ethyl Isocyanate is produced and tested under strict quality management systems. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with industry standards for research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.