Description

Diethyl ((5-((Triisopropylsilyl) Oxy) Pyridin-2-Yl)Methyl) Phosphonate is a high-value organophosphorus compound featuring a protected pyridine-hydroxyl group. This specialized chemical serves as a critical building block in advanced organic synthesis, enabling the precise introduction of functionalized pyridine motifs. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex target molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyridine-containing drug candidates, such as kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate pyridine derivatives.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized phosphonate-based ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the creation of molecular probes and tools for studying biological pathways and enzyme functions.
• Advanced Material Research: Utilized in the synthesis of functional organic molecules for electronic materials or metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Diethyl ((5-((Triisopropylsilyl) Oxy) Pyridin-2-Yl)Methyl) Phosphonate
CAS No.	618386-06-4
Molecular Formula	C20H38NO4PSi
Molecular Weight	415.57 g/mol
Synonyms	Diethyl [(5-[(Triisopropylsilyl)oxy]-2-pyridinyl)methyl]phosphonate; Phosphonic acid, P-[(5-[(triisopropylsilyl)oxy]-2-pyridinyl)methyl]-, diethyl ester; (5-((Triisopropylsilyl)oxy)pyridin-2-yl)methylphosphonic acid diethyl ester; 2-Pyridinemethanol, 5-[(triisopropylsilyl)oxy]-, diethyl phosphonate; TIPS-protected pyridine phosphonate intermediate
EINECS	Contact for details

Quality Control

Our Diethyl ((5-((Triisopropylsilyl) Oxy) Pyridin-2-Yl)Methyl) Phosphonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including NMR, HPLC, and GC-MS. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.