Description

n-[4-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Pyridin-2-Yl]-2,2-Dimethyl-Propionamide is a high-value, protected pyridine derivative featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound is a critical advanced pharmaceutical intermediate (API intermediate) designed for the synthesis of complex active molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates, especially those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its protected hydroxylmethyl functionality on the pyridine ring.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical suppliers offering bespoke synthesis services to the biotech and pharma industries.
• Agrochemical Intermediate: Potential application in the synthesis of advanced, high-performance crop protection agents.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	n-[4-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Pyridin-2-Yl]-2,2-Dimethyl-Propionamide
CAS No.	618107-92-9
Molecular Formula	C18H32N2O2Si
Molecular Weight	336.55 g/mol
Synonyms	2,2-Dimethyl-N-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-pyridinyl]propanamide; N-[4-[(tert-Butyldimethylsilyloxy)methyl]pyridin-2-yl]pivalamide; TBDMS-protected Pyridine Pivalamide; 4-((tert-Butyldimethylsilyloxy)methyl)-N-(2,2-dimethylpropanoyl)pyridin-2-amine; 618107-92-9; Pivalic acid [4-(tert-butyldimethylsilanyloxymethyl)-pyridin-2-yl]-amide
EINECS	Contact for details

Quality Control

Our production of n-[4-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Pyridin-2-Yl]-2,2-Dimethyl-Propionamide adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to fluoride ions and strong alkali; ensure it is stored separately from such materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.