Description

(5-Amino-1-(3-Chloro-4-Fluorophenyl)-1H-Pyrazol-4-Yl)(2-Chlorophenyl)Methanone is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. Pharmaceutical R&D teams and fine chemical manufacturers need this material for developing next-generation drug candidates, where its specific substitution pattern enables targeted biological activity.

Application

This specialized intermediate is designed for high-value synthesis applications, primarily within the life sciences sector.

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its pyrazole core for targeted biological activity.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging agent in the design of chemical probes for studying enzyme function and protein interactions.
• Material Science Research: Investigated as a monomer or additive for creating specialized polymers with unique thermal or optical properties.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis facilities for client-directed projects requiring this specific chemical entity.

Basic Information

Product Name	(5-Amino-1-(3-Chloro-4-Fluorophenyl)-1H-Pyrazol-4-Yl)(2-Chlorophenyl)Methanone
CAS No.	618092-08-3
Molecular Formula	C16H10Cl2FN3O
Molecular Weight	350.18 g/mol
Synonyms	5-Amino-1-(3-chloro-4-fluorophenyl)-1H-pyrazole-4-carboxylic acid 2-chlorophenyl ketone; Methanone, (5-amino-1-(3-chloro-4-fluorophenyl)-1H-pyrazol-4-yl)(2-chlorophenyl)-; 618092-08-3; AKOS025311321; 1-(3-Chloro-4-fluorophenyl)-5-amino-1H-pyrazole-4-yl 2-chlorophenyl ketone; (5-Amino-1-(3-chloro-4-fluorophenyl)-1H-pyrazol-4-yl)(o-chlorophenyl)methanone; AS-64133; ZINC000006074770
EINECS	Contact for details

Quality Control

Our production of (5-Amino-1-(3-Chloro-4-Fluorophenyl)-1H-Pyrazol-4-Yl)(2-Chlorophenyl)Methanone adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization using HPLC, NMR, and MS to ensure structural identity and high purity levels typically exceeding 97%. Certificates of Analysis (COA) detailing purity, impurities, and physical data are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.