Description

(R)-3-Hydroxyglutarate Ethyl tert-Butyl Tbdms is a high-purity chiral building block and protected intermediate of significant synthetic utility. This compound is critical for the stereoselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of statin-class drugs and other therapeutics targeting metabolic disorders.
• Asymmetric Synthesis: Used as a building block in the preparation of complex natural products and bioactive molecules requiring high enantiomeric purity.
• Process Chemistry: Serves as a protected intermediate in the scalable, multi-step synthesis of target compounds under GMP or non-GMP conditions.
• Agrochemical Research: Employed in the development of chiral active ingredients for crop protection agents.
• Academic & Institutional R&D: Utilized in methodological studies and the discovery of new synthetic routes in organic chemistry.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	(R)-3-Hydroxyglutarate Ethyl tert-Butyl Tbdms
CAS No.	615556-99-5
Molecular Formula	C17H36O5Si
Molecular Weight	348.56 g/mol
Synonyms	Ethyl (R)-3-((tert-Butyldimethylsilyl)oxy)-5-oxopentanoate; (R)-Ethyl 3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoate; (R)-3-(tert-Butyldimethylsiloxy)glutaric Acid Ethyl Ester; (R)-3-TBDMS-O-glutaric Acid Ethyl Ester; (R)-3-Hydroxyglutaric Acid Ethyl Ester TBDMS Ether; (R)-3-O-TBDMS Glutarate Ethyl Ester; (R)-3-OTBDMS Glutaric Acid Ethyl Ester; (R)-Ethyl 3-(TBDMSoxy)-5-oxopentanoate
EINECS	Contact for details

Quality Control

Our (R)-3-Hydroxyglutarate Ethyl tert-Butyl Tbdms is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.