Description

tert-Butyl 4-Cyano-4-(Hydroxymethyl)Piperidine-1-Carboxylate is a versatile and high-value piperidine derivative, serving as a critical building block in modern synthetic chemistry. Its bifunctional nature, featuring both a protected amine and reactive nitrile/hydroxymethyl groups, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its piperidine scaffold.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling the exploration of new chemical entities and structure-activity relationships (SAR).
• Peptidomimetics & Bioactive Molecule Construction: The protected amine and functional handles are ideal for creating peptide analogs and other biologically active structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects.

Basic Information

Product Name	tert-Butyl 4-Cyano-4-(Hydroxymethyl)Piperidine-1-Carboxylate
CAS No.	614730-96-0
Molecular Formula	C12H20N2O3
Molecular Weight	240.30 g/mol
Synonyms	1-Boc-4-cyano-4-(hydroxymethyl)piperidine; 4-(Hydroxymethyl)-4-cyano-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-(tert-Butoxycarbonyl)-4-cyano-4-(hydroxymethyl)piperidine; tert-Butyl 4-(Cyanomethyl)-4-hydroxypiperidine-1-carboxylate (tautomeric form); 4-Cyano-4-(hydroxymethyl)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-CN-4-CH2OH-Piperidine; 1-N-Boc-4-cyano-4-hydroxymethylpiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Cyano-4-(Hydroxymethyl)Piperidine-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical applications, and we can accommodate specific customer requirements for analytical methods and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.