Description

Ethyl 5-Bromo-2-Fluorobenzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its value lies in its dual functionalization, providing reactive handles for cross-coupling and further derivatization, which is critical for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and brominated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine and bromine atoms contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic semiconductors and liquid crystal molecules, impacting electronic and display technologies.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Group Transformation: The ester group can be hydrolyzed to the corresponding acid or reduced to the alcohol, enabling diverse synthetic pathways.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development and exploring new synthetic routes to complex organic molecules.

Basic Information

Product Name	Ethyl 5-Bromo-2-Fluorobenzoate
CAS No.	612835-53-7
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	5-Bromo-2-fluorobenzoic acid ethyl ester; Ethyl 5-bromo-2-fluorobenzoate; Benzoic acid, 5-bromo-2-fluoro-, ethyl ester; 2-Fluoro-5-bromobenzoic acid ethyl ester; Ethyl 2-fluoro-5-bromobenzoate; 5-Bromo-2-fluorobenzoic acid, ethyl ester; Ethyl 5-bromo-2-fluorobenzoate (CAS 612835-53-7)
EINECS	Contact for details

Quality Control

Our Ethyl 5-Bromo-2-Fluorobenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for research and process chemistry. Certificates of Analysis (COA) documenting all critical quality attributes are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Typical 99.0%)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.