Description

1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]-5-(3-Fluorophenyl)- is a high-value, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine core with a fluorophenyl substituent. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted kinase inhibitors and other small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Serves as a critical precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Employed in the development of tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis: Starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]-5-(3-Fluorophenyl)-
CAS No.	611226-88-1
Molecular Formula	C19H23FN2Si
Molecular Weight	326.48 g/mol
Synonyms	1-[(1,1-Dimethylethyl)dimethylsilyl]-5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridine; 1-(tert-Butyldimethylsilyl)-5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridine; 5-(3-Fluorophenyl)-1-((tert-butyldimethylsilyl))-1H-pyrrolo[2,3-b]pyridine; 1-TBDMS-5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 1-[(1,1-dimethylethyl)dimethylsilyl]-5-(3-fluorophenyl)-; 1-(tert-Butyldimethylsilyl)-5-(3-fluorophenyl)-7-azaindole; 5-(3-Fluorophenyl)-1H-pyrrolo[2,3-b]pyridine, 1-TBDMS protected; 1-((tert-Butyldimethylsilyl))-5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]-5-(3-Fluorophenyl)- adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under quality agreements and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.