Description

Spiro[Cyclopropane-1,1'-Isoindolin]-3'-One CAS NO 604799-98-6 is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant commercial interest as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, especially those targeting neurological disorders and cancer.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex spirocyclic frameworks, enabling the exploration of new chemical space for biological activity.
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial research programs focused on heterocyclic and strained ring chemistry.
• Process Chemistry: Employed in route scouting and optimization studies for the scalable production of target molecules in pilot plants and commercial manufacturing.

Basic Information

Product Name	Spiro[Cyclopropane-1,1'-Isoindolin]-3'-One
CAS No.	604799-98-6
Molecular Formula	C10H9NO
Molecular Weight	159.19 g/mol
Synonyms	Spiro[cyclopropane-1,1'-isoindolin]-3'-one; 1'H-Spiro[cyclopropane-1,2'-isoindol]-3'(3'H)-one; 3'H-Spiro[cyclopropane-1,1'-isoindole]-3'-one; Spiro(cyclopropane-1,1'-isoindolin)-3'-one; 604799-98-6; Spirocyclopropane-isoindolinone; Spirocyclic isoindolinone derivative
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopropane-1,1'-Isoindolin]-3'-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.