Description

H2N-D-Pro-Ome is a high-purity, non-natural amino acid derivative, specifically the methyl ester of D-Proline. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and protease inhibitors. Its defined stereochemistry and functional groups make it essential for constructing complex molecular architectures with high specificity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for peptide and peptidomimetic drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-proline residues, which can enhance metabolic stability and alter conformational properties of therapeutic peptides.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed as a tool compound in studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Asymmetric Synthesis Catalyst: Can be utilized as a precursor for chiral ligands or organocatalysts in enantioselective transformations.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	H2N-D-Pro-Ome
CAS No.	604003-90-9
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	D-Proline methyl ester; Methyl D-prolinate; (R)-(-)-Proline methyl ester; (R)-2-Pyrrolidinecarboxylic acid methyl ester; D-Pro-OMe; H-D-Pro-OMe; (R)-1-Carbomethoxy-2-pyrrolidine; Methyl (R)-(-)-2-pyrrolidinecarboxylate
EINECS	Contact for details

Quality Control

Our H2N-D-Pro-Ome is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.