Description

Pyrrolidine, 1-(2-Isocyanoethyl)-2,2-Dimethyl- (9Ci) is a specialized heterocyclic building block featuring both a pyrrolidine ring and a reactive isocyanide functional group. This unique bifunctional structure makes it a valuable intermediate for the synthesis of complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel drug candidates, catalysts, and advanced materials. The compound's reactivity allows for the construction of diverse molecular architectures through multicomponent reactions and other advanced synthetic methodologies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging its structural motif to enhance biological activity.
• Catalyst & Ligand Synthesis: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis, including asymmetric synthesis.
• Material Science: Employed in the development of functional polymers, dendrimers, and smart materials where the isocyanide group enables specific cross-linking or functionalization.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and bioconjugates for studying biological processes and protein interactions.
• Multicomponent Reaction (MCR) Chemistry: A critical reactant in Passerini and Ugi-type multicomponent reactions for the efficient generation of chemical libraries in drug discovery.

Basic Information

Product Name	Pyrrolidine, 1-(2-Isocyanoethyl)-2,2-Dimethyl- (9Ci)
CAS No.	602268-94-0
Molecular Formula	C9H16N2
Molecular Weight	152.24 g/mol
Synonyms	1-(2-Isocyanoethyl)-2,2-dimethylpyrrolidine; 2,2-Dimethyl-1-(2-isocyanoethyl)pyrrolidine; 2-(2,2-Dimethylpyrrolidin-1-yl)ethyl isocyanide; 1-(2-Isocyanatoethyl)-2,2-dimethylpyrrolidine (common misnomer); Isocyanide C9 building block
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 1-(2-Isocyanoethyl)-2,2-Dimethyl- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.