Description

L-Proline, 1-(3-Isocyanopropyl)-, Ethyl Ester (9Ci) CAS NO 602268-69-9 is a specialized proline derivative featuring a reactive isocyanate group, making it a valuable building block in organic synthesis and peptide chemistry. This compound is engineered to serve as a key intermediate for the development of novel pharmaceutical agents, bioactive peptides, and advanced materials. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of peptide-based drugs, prodrugs, and targeted therapeutic agents.
• Peptide Modification: Used to introduce isocyanate-functionalized side chains into peptides for conjugation, labeling, or creating novel peptide mimetics.
• Chemical Biology Probes: Serves as a building block for developing activity-based probes (ABPs) and other tools to study enzyme function and protein interactions.
• Material Science: Employed in the creation of functional polymers, hydrogels, and coatings through its reactive isocyanate group.
• Agrochemical Research: Acts as an intermediate in the design and synthesis of new crop protection agents and plant growth regulators.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	L-Proline, 1-(3-Isocyanopropyl)-, Ethyl Ester (9Ci)
CAS No.	602268-69-9
Molecular Formula	C12H20N2O3
Molecular Weight	240.30 g/mol
Synonyms	1-(3-Isocyanopropyl)-L-proline ethyl ester; Ethyl 1-(3-isocyanopropyl)-L-prolinate; L-Proline, 1-(3-isocyanopropyl)-, ethyl ester; (S)-1-(3-Isocyanopropyl)pyrrolidine-2-carboxylic acid ethyl ester; Proline derivative with isocyanate; Isocyanate-functionalized proline ester; N-(3-Isocyanopropyl)-L-proline ethyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 1-(3-Isocyanopropyl)-, Ethyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, enantiomeric purity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from moisture, heat, and incompatible materials such as strong acids, bases, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Isocyanate Content (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.