Description

1-(2-Isocyano-Ethyl)-4-Pyridin-2-Yl-Piperazine is a specialized heterocyclic building block featuring both an isocyano and a piperazine-pyridine moiety. This compound is of significant value in medicinal chemistry and pharmaceutical research as a versatile intermediate for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) targeted research.
• Medicinal Chemistry Scaffold: Used for constructing diverse compound libraries via its reactive isocyano group for multicomponent reactions and cyclizations.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides, leveraging its heterocyclic structure.
• Ligand Synthesis: Utilized in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and biological pathways.

Basic Information

Product Name	1-(2-Isocyano-Ethyl)-4-Pyridin-2-Yl-Piperazine
CAS No.	602267-26-5
Molecular Formula	C12H16N4
Molecular Weight	216.28 g/mol
Synonyms	1-(2-Isocyanoethyl)-4-(pyridin-2-yl)piperazine; 4-(2-Pyridyl)-1-(2-isocyanoethyl)piperazine; 2-(4-(Pyridin-2-yl)piperazin-1-yl)ethyl isocyanide; 1-(2-Isocyanatoethyl)-4-(2-pyridyl)piperazine (common misnomer); 1-(2-Isocyano-ethyl)-4-pyridin-2-yl-piperazine; 2-Pyridylpiperazine isocyanide derivative; N-(2-Isocyanoethyl)-N'-(2-pyridyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-(2-Isocyano-Ethyl)-4-Pyridin-2-Yl-Piperazine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.