Description

Benzene, 4-Chloro-2-Fluoro-1-Isocyano- (9Ci) is a specialized aromatic isocyanide derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents adjacent to the highly reactive isocyano group, makes it a critical intermediate for constructing complex heterocyclic and pharmaceutical scaffolds. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce functional diversity into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Employed in organometallic chemistry for the preparation of specialized isocyanide ligands used in catalysis and material science applications.
• Heterocyclic Chemistry: A versatile reactant for constructing a wide range of nitrogen-containing heterocycles, such as indoles, quinolines, and imidazoles, via multi-component reactions.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes and tags for studying biological processes due to its bio-orthogonal reactivity.
• Polymer & Material Science: Acts as a monomer or functionalization agent in the synthesis of specialty polymers and advanced materials with tailored properties.

Basic Information

Item	Detail
Product Name	Benzene, 4-Chloro-2-Fluoro-1-Isocyano- (9Ci)
CAS No.	602262-00-0
Molecular Formula	C7H3ClF N
Molecular Weight	155.56 g/mol
Synonyms	4-Chloro-2-fluorophenyl isocyanide; 1-Chloro-4-fluoro-2-isocyanobenzene; 2-Fluoro-4-chlorophenyl isocyanide; 4-Chloro-2-fluoro-1-isocyanobenzene; 2-Fluoro-4-chloro phenyl isonitrile; (4-Chloro-2-fluorophenyl)isocyanide; Isocyanide, (4-chloro-2-fluorophenyl)-; 1-Isocyano-4-chloro-2-fluorobenzene
EINECS	Contact for details

Quality Control

Our Benzene, 4-Chloro-2-Fluoro-1-Isocyano- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including NMR, HPLC, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and adherence to ISO 9001 standards underpin our reliable supply chain for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to the reactive nature of the isocyano group and potential sensitivity, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.