Description

Benzene, 2-Chloro-1-Fluoro-4-Isocyano- (9Ci) is a specialized halogenated aromatic isocyanide building block, identified by CAS NO 602261-99-4. This compound is of significant value in advanced organic synthesis due to its reactive isocyano group and the electronic influence of its chloro and fluoro substituents. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting heterocyclic compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the halogenated benzene core contributes to biological activity.
• Ligand Synthesis in Catalysis: Serves as a building block for creating specialized isocyanide ligands used in transition metal catalysis, such as palladium-catalyzed cross-coupling reactions.
• Material Science: Employed in the research and development of advanced organic materials, including polymers and liquid crystals with tailored electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes, leveraging the isocyano group for bioorthogonal labeling.

Basic Information

Product Name	Benzene, 2-Chloro-1-Fluoro-4-Isocyano- (9Ci)
CAS No.	602261-99-4
Molecular Formula	C7H3ClF N
Molecular Weight	155.56 g/mol
Synonyms	2-Chloro-1-fluoro-4-isocyanobenzene; 1-Fluoro-2-chloro-4-isocyanobenzene; 4-Isocyano-2-chloro-1-fluorobenzene; 2-Chloro-1-fluoro-4-isocyano-benzene; 2-Chloro-1-fluoro-4-isocyanobenzene (9CI); 2-Chloro-1-fluoro-4-isocyano-Benzene; 2-Chloro-1-fluoro-4-isocyano benzene; Benzene, 2-chloro-1-fluoro-4-isocyano-
EINECS	Contact for details

Quality Control

Our Benzene, 2-Chloro-1-Fluoro-4-Isocyano- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including NMR, HPLC, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.