Description

2-Methoxybenzylisocyanide is a versatile and highly reactive organic building block, specifically an isocyanide derivative of o-methoxybenzyl alcohol. Its value lies in its role as a critical reagent in multicomponent reactions, enabling the efficient synthesis of complex heterocyclic scaffolds and natural product analogs. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for advanced synthetic applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly via Ugi and Passerini multicomponent reactions.
• Agrochemical Research: Used in the development of new pesticides and herbicides through the construction of nitrogen-containing heterocycles.
• Material Science: Serves as a monomer or ligand precursor in the development of functional polymers and metal-organic frameworks (MOFs).
• Chemical Biology: Employed in bioorthogonal chemistry and as a probe for studying biological processes.
• Academic & R&D: Fundamental reagent in organic synthesis laboratories for methodology development and complex molecule construction.
• Catalyst Ligand Synthesis: Precursor for isocyanide-derived ligands used in transition metal catalysis.

Basic Information

Product Name	2-Methoxybenzylisocyanide
CAS No.	602261-92-7
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	o-Methoxybenzyl isocyanide; (2-Methoxyphenyl)methyl isocyanide; 1-Isocyano-1-(2-methoxyphenyl)methane; 2-Methoxybenzyl isonitrile; 2-Methoxybenzyl Isocyanide; o-Methoxybenzylisonitrile; 2-Methoxybenzyl Isonitrile; (2-Methoxyphenyl)methylisonitrile
EINECS	Contact for details

Quality Control

Our 2-Methoxybenzylisocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of research and development in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.