Description

2-Chloro-5-(Trifluoromethyl)Phenyl Isocyanide is a versatile and highly reactive aromatic isocyanide building block. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules in advanced chemical synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in the development of protease inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science: Serves as a precursor for functional polymers, liquid crystals, and organic electronic materials due to its rigid aromatic core and reactive isocyanide group.
• Catalyst & Ligand Development: Employed in the design and synthesis of novel organometallic catalysts and ligands for asymmetric synthesis and cross-coupling reactions.
• Chemical Biology & Proteomics: Utilized in bioorthogonal chemistry and activity-based protein profiling (ABPP) as a reactive handle for labeling biomolecules.
• Heterocyclic Chemistry: A crucial reactant in multicomponent reactions (MCRs), such as the Ugi and Passerini reactions, to generate diverse libraries of nitrogen-containing heterocycles.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Phenyl Isocyanide
CAS No.	601465-68-3
Molecular Formula	C8H3ClF3N
Molecular Weight	205.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-tolyl isocyanide; 1-Chloro-4-isocyano-2-(trifluoromethyl)benzene; 2-Chloro-5-(trifluoromethyl)benzenecarbonitrile, Isocyano-; 2-Chloro-α,α,α-trifluoro-p-tolyl isonitrile; 2-Chloro-5-(trifluoromethyl)phenyl isonitrile; 2-Chloro-5-(trifluoromethyl)benzenisocyanide; Isocyanide, 2-chloro-5-(trifluoromethyl)phenyl-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Phenyl Isocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.