Description

7-[2-(Cyclopropylmethoxy)-6-Hydroxyphenyl]-1,4-Dihydro-5-(3S)-3-Piperidinyl-2H-Pyrido[2,3-D][1,3]Oxazin-2-One is a high-purity, non-racemic chiral compound with a complex heterocyclic structure, serving as a critical advanced pharmaceutical intermediate. Its precise stereochemistry and functional groups make it a valuable building block for the synthesis of novel, targeted therapeutic agents. This compound is primarily required by research institutions and pharmaceutical companies engaged in the development of new chemical entities (NCEs), particularly in oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used as a core scaffold or precursor in medicinal chemistry for structure-activity relationship (SAR) studies.
• Preclinical Development: Serves as a critical material for producing batches of candidate drugs for pharmacological and toxicological evaluation.
• Process Chemistry: Employed in route scouting and optimization for the scalable synthesis of complex drug molecules.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for target identification and validation in biological systems.

Basic Information

Product Name	7-[2-(Cyclopropylmethoxy)-6-Hydroxyphenyl]-1,4-Dihydro-5-(3S)-3-Piperidinyl-2H-Pyrido[2,3-D][1,3]Oxazin-2-One
CAS No.	600734-02-9
Molecular Formula	C22H25N3O4
Molecular Weight	395.45 g/mol
Synonyms	(3S)-5-(3-Piperidinyl)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one; 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one; UNII-6Q3U6E6W1F; 6Q3U6E6W1F; BMS-817378; BMS 817378; BMS817378; (S)-Enantiomer of the pyridoxazinone derivative.
EINECS	Contact for details

Quality Control

Our 7-[2-(Cyclopropylmethoxy)-6-Hydroxyphenyl]-1,4-Dihydro-5-(3S)-3-Piperidinyl-2H-Pyrido[2,3-D][1,3]Oxazin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade and cGMP-for-intermediate standards where applicable. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.