Description

Pyrrolidine, 1-[1-Thioxo-2-(Trimethylsilyl)Ethyl]- (9Ci) is a specialized organosilicon compound featuring a pyrrolidine backbone modified with a thioxo and trimethylsilylethyl group. This unique structure makes it a valuable advanced synthetic intermediate for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working in medicinal chemistry, process scale-up, and fine chemical synthesis. The compound's reactivity is leveraged for introducing specific functional groups and protecting strategies in multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing nitrogen heterocycles.
• Agrochemical Research: Used in the development and optimization of new herbicides, fungicides, and insecticides requiring specific silicon-containing motifs.
• Organometallic Chemistry: Acts as a ligand precursor or a modifying agent in catalytic systems and metal-organic frameworks (MOFs).
• Peptidomimetics & Bioactive Molecule Synthesis: Employed to create pyrrolidine-based scaffolds that mimic peptide structures for drug discovery.
• Material Science Research: Utilized in the synthesis of specialty polymers, coatings, or silicon-based functional materials.
• Academic & Industrial R&D: A versatile reagent for methodological development and exploring new chemical reactions in organic synthesis.

Basic Information

Product Name	Pyrrolidine, 1-[1-Thioxo-2-(Trimethylsilyl)Ethyl]- (9Ci)
CAS No.	600728-19-6
Molecular Formula	C9H19NSSi
Molecular Weight	201.40 g/mol
Synonyms	1-(1-Thioxo-2-(trimethylsilyl)ethyl)pyrrolidine; 1-[1-Thioxo-2-(trimethylsilyl)ethyl]pyrrolidine; 2-(Trimethylsilyl)-1-pyrrolidin-1-ylethanethione; N-[(Trimethylsilyl)acetyl]pyrrolidine-1-carbothioamide; (Trimethylsilyl)acetylpyrrolidine carbothioamide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific batch results are available upon request. We adhere to a cGMP-compliant quality management system to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.