Description

Quadazocine is a synthetic opioid antagonist with a distinct chemical structure, primarily recognized for its pharmacological research applications. This compound is valued for its specific receptor binding profile, making it a critical reference standard and investigative tool in neuropharmacology and medicinal chemistry. Key industries that utilize this material include pharmaceutical R&D, analytical testing laboratories, and academic institutions focused on central nervous system drug discovery.

Application

• Pharmacological Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for method development and validation in drug testing.
• Neuroscience Research: Serves as a key tool compound for studying opioid receptor (particularly κ-opioid receptor) interactions, signaling pathways, and antagonist effects.
• Medicinal Chemistry Development: Employed as a lead compound or structural analog in the design and synthesis of new opioid antagonists with potential therapeutic applications.
• Biochemical Assays: Utilized in in vitro receptor binding assays and functional studies to determine affinity, efficacy, and selectivity profiles.
• Academic & Institutional Research: Supports fundamental research in universities and government labs exploring pain mechanisms, addiction, and neuropsychiatric disorders.
• Quality Control in Manufacturing: Acts as a system suitability standard in the quality control of related pharmaceutical substances and finished dosage forms.

Basic Information

Product Name	Quadazocine
CAS No.	69924-29-4
Molecular Formula	C24H30N2O2
Molecular Weight	378.51 g/mol
Synonyms	WIN 44,441; Quadazocine mesylate; 2-(Cyclopropylmethyl)-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan; 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(cyclopropylmethyl)-2,6-methano-3-benzazocin-8-ol; MR 2034; Benzomorphan derivative; Opioid antagonist MR 2034; Cyclazocine analog
EINECS	Contact for details

Quality Control

Our Quadazocine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identification by IR and NMR, purity determination by HPLC, and control of related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our internal specifications and supporting its use as a reference material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.