Description

3-(Trimethylsiloxy)-5α-Androst-3-En-17-One is a high-purity steroidal intermediate featuring a strategically protected 3-hydroxy group via a trimethylsilyl (TMS) ether. This compound is critical for enabling selective synthetic transformations in complex organic synthesis, particularly where sensitive functional groups are present. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel steroid-based therapeutics and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of advanced steroid-based active pharmaceutical ingredients (APIs) and hormone analogs.
• Organic Synthesis Reagent: Used as a protected precursor in research-scale and process chemistry for the selective manipulation of steroid cores.
• Biochemical Research: Employed in academic and industrial laboratories studying steroid metabolism, receptor interactions, and biosynthetic pathways.
• Fine Chemical Production: Serves as a specialized intermediate in the manufacture of high-value, low-volume fine chemicals and reference standards.

Basic Information

Product Name	3-(Trimethylsiloxy)-5α-Androst-3-En-17-One
CAS No.	69833-85-8
Molecular Formula	C22H38O2Si
Molecular Weight	362.62 g/mol
Synonyms	5α-Androst-3-en-17-one, 3-[(trimethylsilyl)oxy]-; 3-Trimethylsiloxy-5α-androst-3-en-17-one; 5α-Androst-3-en-17-one 3-trimethylsilyl ether; Androst-5-en-17-one, 3-(trimethylsilyl)oxy]- (5α)-; 69833-85-8; 3-TMS-androst-5-en-17-one; 3-O-Trimethylsilyl-5α-androst-3-en-17-one
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsiloxy)-5α-Androst-3-En-17-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets stringent specifications for research and process use. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.