Description

3,15β,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene is a high-purity, organosilicon-protected derivative of estradiol, designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise, moisture-sensitive intermediates in complex organic synthesis. It is primarily utilized in the pharmaceutical and fine chemical industries for the development of novel steroid-based therapeutics and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key protected intermediate in the multi-step synthesis of novel steroidal drugs and hormone analogs.
• Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and structure-activity relationships (SAR) in steroid chemistry.
• Fine Chemical Synthesis: Serves as a building block for creating complex, high-value specialty chemicals with specific stereochemical configurations.
• Process Chemistry: Employed in scale-up and process optimization for the production of active pharmaceutical ingredients (APIs) where protecting group chemistry is essential.

Basic Information

Item	Details
Product Name	3,15β,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene
CAS No.	69833-74-5
Molecular Formula	C27H48O3Si3
Molecular Weight	504.93 g/mol
Synonyms	1,3,5(10)-Estratriene-3,15β,17β-triol, tris(trimethylsilyl) ether; Tris(trimethylsilyl) Ether of Estradiol; 3,15β,17β-Tris-O-(trimethylsilyl)estradiol; Estradiol-3,15β,17β-tris(trimethylsilyl ether); TMS-Estradiol Derivative; 69833-74-5; Estratriene tris(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 3,15β,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.