Description

1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Mannopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly functionalized, fully protected derivative of D-mannose, featuring multiple trimethylsilyl (TMS) protecting groups and a phosphoric acid bis(trimethylsilyl) ester moiety. This compound is a critical advanced intermediate in synthetic organic chemistry, valued for its role in constructing complex carbohydrate-based molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleoside analogs, antiviral agents, and other sophisticated bioactive compounds where controlled glycosylation and phosphorylation are required.

Application

• Synthesis of Nucleoside Analogs: Serves as a key phosphorylated and protected sugar precursor for the construction of modified nucleosides with potential antiviral or anticancer activity.
• Carbohydrate Chemistry Research: Used as a versatile building block in the synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Pharmaceutical Intermediate: Acts as a critical advanced intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly those targeting viral infections.
• Prodrug Development: The protected phosphate ester group can be utilized in the design of prodrug strategies to enhance the bioavailability of phosphate-containing drugs.
• Chemical Biology Probes: Employed in the creation of labeled or tagged carbohydrate probes for studying biological recognition and signaling pathways.
• Process Development & Scale-up: Supplied for route scouting and optimization in process chemistry for the efficient production of carbohydrate-based therapeutics.

Basic Information

Item	Details
Product Name	1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Mannopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	69744-65-6
Molecular Formula	C24H61O9PSi6
Molecular Weight	677.28 g/mol
Synonyms	D-Mannopyranose, 1-O,2-O,3-O,4-o-tetrakis-O-(trimethylsilyl)-, cyclic 5,6-(hydrogen phosphate) bis(trimethylsilyl) ester; 1,2,3,4-Tetra-O-trimethylsilyl-D-mannopyranose 5,6-cyclic hydrogenphosphonate bis(trimethylsilyl) ester; Protected D-Mannose Phosphotriester; TMS-protected Mannose Phosphorylating Agent; CAS 69744-65-6
EINECS	Contact for details

Quality Control

Every batch of 1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Mannopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure high chemical purity and structural integrity suitable for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (argon or nitrogen) when opening the container to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.